NOGGIN: a new therapeutic target for PH? Focus on “Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels”
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NOGGIN: a new therapeutic target for PH? Focus on "Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels".
PULMONARY ARTERIAL HYPERTENSION (PAH) is a rare and often fatal disease characterized by sustained and progressive elevation of mean pulmonary arterial pressure with pathological changes involving vasoconstriction, vascular remodeling, and inflammation, leading to right ventricular hypertrophy and heart failure (6). Endothelial dysfunction and subsequent excessive proliferation of smooth muscle...
متن کاملNoggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels.
Abnormally elevated bone morphogenetic protein 4 (BMP4) expression and mediated signaling play a critical role in the pathogenesis of chronic hypoxia-induced pulmonary hypertension (CHPH). In this study, we investigated the expression level and functional significance of four reported naturally occurring BMP4 antagonists, noggin, follistatin, gremlin1, and matrix gla protein (MGP), in the lung ...
متن کاملNoggin Inhibits Hypoxia-induced Proliferation by Targeting Store-operated Calcium Entry
Noggin Inhibits Hypoxia-induced Proliferation by Targeting Store-operated Calcium Entry 1 and Transient Receptor Potential Cation Channels 2 3 4 Kai Yang , Jing Jia, Jie Zhang, Mingming Zhao, Sabrina Wang, Haiyang Jiang, Lei Xu , 5 Wenju Lu and Jian Wang 2 6 7 Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Diseases, The 1 8 Affiliated Hospital of Guangzhou Medic...
متن کاملStore-operated calcium channels.
Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in virtually all metozoan cells and serve a wide variety of functions ranging from gene expression, motility, and secretion to tissue and organ development and the immune response. SOCs are activated by the depletion of Ca(2+) from the endoplasmic reticulum (ER), triggered physiologically through stimulation of a d...
متن کاملStore-operated calcium channels.
In electrically nonexcitable cells, Ca(2+) influx is essential for regulating a host of kinetically distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and proliferation, and apoptosis. The major Ca(2+) entry pathway in these cells is the store-operated one, in which the emptying of intracellular Ca(2+) stores activates Ca(2+) influx (store-operated Ca(2+) entr...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2015
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00088.2015